Joshua R. Berlin, Ph.D. * - Newark - Voltage-dependent reaction steps in ion transport using the Na,K-ATPase as a model system. Ion transport kinetics are measured by patch-clamp in cardiac myocytes and HeLa cells expressing Na,K-ATPase enzymes containing point mutations. We also are studying Cardiac muscle excitation-contraction coupling and calcium influx.
Joel A. DeLisa, M.D., M.S. * - Newark - Spinal Cord Injury - Spasticity. Regeneration, Electrodiagnostic Evaluation Systems of Clinical Care.
Joseph Kedem, Ph.D. * - Piscataway - Relationship between local myocardial function and energy metabolism. Effects of various types of ischemic damage on efficiency of cardiac contraction. In vivo experiments and mathematical analyses.
John P. Reeves, Ph.D. * - Newark - The Na/Ca exchange system is the principal Ca efflux mechanism in cardiac muscle cells and plays an important role in regulating cardiac contractility. We study the cellular mechanisms that control the activity of this important transporter using molecular and Ca imaging techniques.
Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.
Donald A. Winkelmann, Ph.D. * - Piscataway - Study of macromolecular structure and assembly with our efforts concentrated on the analysis of the protein myosin and its interaction with actin.
