Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.
Walter N. Duran, Ph.D. * - Newark - Signaling between the vascular wall and blood cells: 1) role of NOS in hyperpermeability induced by inflammatory agents; 2) signaling pathways in the control of permeability 3) permeability alterations associated with microvascular dysfunction. We use intravital microscopy, computer-assisted image analysis, Western blotting, and reverse transcriptase PCR.
Grant Gallagher, Ph.D. - Newark - This is a newly established lab whose main interests are 1) the genetics of cytokines in bone loss, autoimmunity, inflammation and cancer, especially IL10, TNF and the chemokines; 2) the immunology and genetics of the IL-10 homologs and their receptors, especially IL-19, IL-20 and IL-24.
Carl J. Hauser, M.D. - Newark - My laboratory studies neutrophil functional responses in the inflammatory cytokine milieu generated by trauma. We have a special interest in the cross regulation of G-protein coupled receptors and the mechanisms of their mobilization of cell calcium under such conditions.
Carl Hock, Ph.D. * - Stratford - Current work is focused on the effect of humoral mediators and inflammatory cells in the pathophysiology of ischemic states, the effects of dietary lipids on cardiovascular function and the response of the young and aging heart to ischemia and reperfusion. Email: hock@umdnj.edu
S. Joseph Leibovich, Ph.D. * - Newark - Role of macrophages, nitric oxide and oxygen in regulation of angiogenesis in wound healing and cancer. Analysis of VEGF expression in macrophages and its regulation by nitric oxide. Role of ADP-ribosylation of VEGF in macrophages and its role in regulation of angiogenesis.
Steven W Levison, Ph.D. * - Newark - The goal of Dr. Levison’s research is to enhance regeneration of the CNS from its resident stem cells and to understand the impact of neuroinflammation using cell culture and animal models of multiple sclerosis, neonatal hypoxia ischemia, traumatic brain injury and stroke.
Peitan Liu, M.D/Ph.D. * - Stratford - Work in the laboratory concerns the role of cytokines and reactive oxygen species in ischemia-reperfusion injury. Currently we focus on the study of myocyte apoptosis, particularly the role of Mdm2/p53-mediated apoptosis, in aged rat model of myocardial ischemia-reperfusion. Email: liupe@umdnj.edu
David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.
Robert Nagele, Ph.D. * - Stratford - My laboratory is focused on elucidating the role of breakdown of the blood-brain barrier in the initiation and progression of Alzheimer`s disease and developing therapeutic strategies aimed at preventing this breakdown and the leak of potentially damaging blood components into the brain tissue. In addition, my laboratory is collaborating with the Coriell Institute to develop methods to isolate and grow adult human stem cells with the goal of generating large quantities of these cells that retain their stem cell and therapeutic potential. Email: nagelero@umdnj.edu
Andrew R. Pachner, M.D. * - Newark - We focus on detection of pathogen and characterization of host immune response in infections of the nervous system, particularly Lyme borreliosis. We extensively use molecular biological tools, such as PCR and microarrays.
Christine M. Rohowsky-Kochan, Ph.D. * - Newark - Studies focus on the nature and regulation of autoreactive T cells in multiple sclerosis and on the viral etiology of multiple sclerosis. Emphasis is on the role of cytokines and their control. Utilize immunological and molecular techniques.
Bernd W. Spur, Ph.D. * - Stratford - We focus on mediators of inflammation, including prostaglandins, phytoprostanes, leukotrienes, lipoxins, resolvins, neuroprotectins, docosatrienes as well as isoprostanes. These mediators are prepared in the natural and isotopically labelled form to explore their biological activities and serve as markers in inflammatory diseases such as Asthma and Alzheimer. Email: spurbw@umdnj.edu
Kingsley Yin, Ph.D. * - Stratford - Research focuses on cytokines and other inflammatory mediators in sepsis. The role of interferon-gamma and monocyte chemoattractant protein-1 in lung injury during sepsis is being investigated. Email: yinki@umdnj.edu
